Búsqueda | Portal de Búsqueda de la BVS

1.

Fine-Tuning Cytokine Signals.

Lin, Jian-Xin; Leonard, Warren J.

Annu Rev Immunol ; 37: 295-324, 2019 04 26.

Artículo en Inglés | MEDLINE | ID: mdl-30649989

2.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin, Annie; Masson, Frederick; Liao, Yang; Preston, Simon; Guan, Tianxia; Gloury, Renee; Olshansky, Moshe; Lin, Jian-Xin; Li, Peng; Speed, Terence P; Smyth, Gordon K; Ernst, Matthias; Leonard, Warren J; Pellegrini, Marc; Kaech, Susan M; Nutt, Stephen L; Shi, Wei; Belz, Gabrielle T; Kallies, Axel.

Nat Immunol ; 17(4): 422-32, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26950239

3.

The Î³_c Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Leonard, Warren J; Lin, Jian-Xin; O'Shea, John J.

Immunity ; 50(4): 832-850, 2019 04 16.

Artículo en Inglés | MEDLINE | ID: mdl-30995502

4.

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection.

Hudson, William H; Gensheimer, Julia; Hashimoto, Masao; Wieland, Andreas; Valanparambil, Rajesh M; Li, Peng; Lin, Jian-Xin; Konieczny, Bogumila T; Im, Se Jin; Freeman, Gordon J; Leonard, Warren J; Kissick, Haydn T; Ahmed, Rafi.

Immunity ; 51(6): 1043-1058.e4, 2019 12 17.

Artículo en Inglés | MEDLINE | ID: mdl-31810882

5.

Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Kalbasi, Anusha; Siurala, Mikko; Su, Leon L; Tariveranmoshabad, Mito; Picton, Lora K; Ravikumar, Pranali; Li, Peng; Lin, Jian-Xin; Escuin-Ordinas, Helena; Da, Tong; Kremer, Sarah V; Sun, Amy L; Castelli, Sofia; Agarwal, Sangya; Scholler, John; Song, Decheng; Rommel, Philipp C; Radaelli, Enrico; Young, Regina M; Leonard, Warren J; Ribas, Antoni; June, Carl H; Garcia, K Christopher.

Nature ; 607(7918): 360-365, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35676488

6.

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Hashimoto, Masao; Araki, Koichi; Cardenas, Maria A; Li, Peng; Jadhav, Rohit R; Kissick, Haydn T; Hudson, William H; McGuire, Donald J; Obeng, Rebecca C; Wieland, Andreas; Lee, Judong; McManus, Daniel T; Ross, James L; Im, Se Jin; Lee, Junghwa; Lin, Jian-Xin; Hu, Bin; West, Erin E; Scharer, Christopher D; Freeman, Gordon J; Sharpe, Arlene H; Ramalingam, Suresh S; Pellerin, Alex; Teichgräber, Volker; Greenleaf, William J; Klein, Christian; Goronzy, Jorg J; Umaña, Pablo; Leonard, Warren J; Smith, Kendall A; Ahmed, Rafi.

Nature ; 610(7930): 173-181, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36171288

7.

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

Mo, Fei; Yu, Zhiya; Li, Peng; Oh, Jangsuk; Spolski, Rosanne; Zhao, Liang; Glassman, Caleb R; Yamamoto, Tori N; Chen, Yun; Golebiowski, Filip M; Hermans, Dalton; Majri-Morrison, Sonia; Picton, Lora K; Liao, Wei; Ren, Min; Zhuang, Xiaoxuan; Mitra, Suman; Lin, Jian-Xin; Gattinoni, Luca; Powell, Jonathan D; Restifo, Nicholas P; Garcia, K Christopher; Leonard, Warren J.

Nature ; 597(7877): 544-548, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34526724

8.

Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.

Yang, Huilin; Ulge, Umut Y; Quijano-Rubio, Alfredo; Bernstein, Zachary J; Maestas, David R; Chun, Jung-Ho; Wang, Wentao; Lin, Jian-Xin; Jude, Kevin M; Singh, Srujan; Orcutt-Jahns, Brian T; Li, Peng; Mou, Jody; Chung, Liam; Kuo, Yun-Huai; Ali, Yasmin H; Meyer, Aaron S; Grayson, Warren L; Heller, Nicola M; Garcia, K Christopher; Leonard, Warren J; Silva, Daniel-Adriano; Elisseeff, Jennifer H; Baker, David; Spangler, Jamie B.

Nat Chem Biol ; 19(9): 1127-1137, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37024727

9.

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Ring, Aaron M; Lin, Jian-Xin; Feng, Dan; Mitra, Suman; Rickert, Mathias; Bowman, Gregory R; Pande, Vijay S; Li, Peng; Moraga, Ignacio; Spolski, Rosanne; Ozkan, Engin; Leonard, Warren J; Garcia, K Christopher.

Nat Immunol ; 13(12): 1187-95, 2012 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-23104097

10.

Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation.

Monaghan, Kelly L; Aesoph, Drake; Ammer, Amanda G; Zheng, Wen; Rahimpour, Shokofeh; Farris, Breanne Y; Spinner, Camille A; Li, Peng; Lin, Jian-Xin; Yu, Zu-Xi; Lazarevic, Vanja; Hu, Gangqing; Leonard, Warren J; Wan, Edwin C K.

Proc Natl Acad Sci U S A ; 118(52)2021 12 28.

Artículo en Inglés | MEDLINE | ID: mdl-34934004

11.

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Liao, Wei; Lin, Jian-Xin; Wang, Lu; Li, Peng; Leonard, Warren J.

Nat Immunol ; 12(6): 551-9, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21516110

12.

Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Kalbasi, Anusha; Siurala, Mikko; Su, Leon L; Tariveranmoshabad, Mito; Picton, Lora K; Ravikumar, Pranali; Li, Peng; Lin, Jian-Xin; Escuin-Ordinas, Helena; Da, Tong; Kremer, Sarah V; Sun, Amy L; Castelli, Sofia; Agarwal, Sangya; Scholler, John; Song, Decheng; Rommel, Philipp C; Radaelli, Enrico; Young, Regina M; Leonard, Warren J; Ribas, Antoni; June, Carl H; Garcia, K Christopher.

Nature ; 612(7938): E10, 2022 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-36380037

13.

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity.

Hermans, Dalton; Gautam, Sanjivan; García-Cañaveras, Juan C; Gromer, Daniel; Mitra, Suman; Spolski, Rosanne; Li, Peng; Christensen, Stephen; Nguyen, Rosa; Lin, Jian-Xin; Oh, Jangsuk; Du, Ning; Veenbergen, Sharon; Fioravanti, Jessica; Ebina-Shibuya, Risa; Bleck, Christopher; Neckers, Leonard M; Rabinowitz, Joshua D; Gattinoni, Luca; Leonard, Warren J.

Proc Natl Acad Sci U S A ; 117(11): 6047-6055, 2020 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-32123114

14.

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.

Liao, Wei; Lin, Jian-Xin; Leonard, Warren J.

Immunity ; 38(1): 13-25, 2013 Jan 24.

Artículo en Inglés | MEDLINE | ID: mdl-23352221

15.

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade.

Jadhav, Rohit R; Im, Se Jin; Hu, Bin; Hashimoto, Masao; Li, Peng; Lin, Jian-Xin; Leonard, Warren J; Greenleaf, William J; Ahmed, Rafi; Goronzy, Jorg J.

Proc Natl Acad Sci U S A ; 116(28): 14113-14118, 2019 07 09.

Artículo en Inglés | MEDLINE | ID: mdl-31227606

16.

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Wang, Hongsheng; Jain, Shweta; Li, Peng; Lin, Jian-Xin; Oh, Jangsuk; Qi, Chenfeng; Gao, Yuanyuan; Sun, Jiafang; Sakai, Tomomi; Naghashfar, Zohreh; Abbasi, Sadia; Kovalchuk, Alexander L; Bolland, Silvia; Nutt, Stephen L; Leonard, Warren J; Morse, Herbert C.

Proc Natl Acad Sci U S A ; 116(19): 9511-9520, 2019 05 07.

Artículo en Inglés | MEDLINE | ID: mdl-31000603

17.

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.

Lin, Jian-Xin; Li, Peng; Liu, Delong; Jin, Hyun Tak; He, Jianping; Ata Ur Rasheed, Mohammed; Rochman, Yrina; Wang, Lu; Cui, Kairong; Liu, Chengyu; Kelsall, Brian L; Ahmed, Rafi; Leonard, Warren J.

Immunity ; 36(4): 586-99, 2012 Apr 20.

Artículo en Inglés | MEDLINE | ID: mdl-22520852

18.

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.

Li, Peng; Mitra, Suman; Spolski, Rosanne; Oh, Jangsuk; Liao, Wei; Tang, Zhonghui; Mo, Fei; Li, Xingwang; West, Erin E; Gromer, Daniel; Lin, Jian-Xin; Liu, Chengyu; Ruan, Yijun; Leonard, Warren J.

Proc Natl Acad Sci U S A ; 114(46): 12111-12119, 2017 11 14.

Artículo en Inglés | MEDLINE | ID: mdl-29078395

19.

Possible Human Papillomavirus 38 Contamination of Endometrial Cancer RNA Sequencing Samples in The Cancer Genome Atlas Database.

Kazemian, Majid; Ren, Min; Lin, Jian-Xin; Liao, Wei; Spolski, Rosanne; Leonard, Warren J.

J Virol ; 89(17): 8967-73, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26085148

20.

Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer.